The IMSE Materials for Regenerative Medicine research concentration comprises two areas:
- Synthesis of bio-inspired materials
- Understanding the material properties of tissues and biomaterials
Synthesis of bio-inspired materials (Elbert, Genin, Maurer, Sakiyama-Elbert, Thomopoulos)
Biomedical materials research at Washington University is focused on the manipulation of the biological and cellular processes that occur on or within materials. Materials are being designed that:
- Promote the attachment and growth of cells in contact with materials
- Release drugs with predictable kinetics.
- Exhibit spatial organization over different length scales
Understanding the material properties of tissues and biomaterials (Genin, Lake, Pasteris, Silva, Tang, Thomopoulos)
A better understanding of structure-function relationships in biological tissues will allow us to predict and prevent injury due to trauma, or to predict the progression of several genetic diseases. Such studies quantify how compositional and organizational properties lead to inhomogeneous and anisotropic mechanical properties required for adequate function in vivo, and characterize changes that occur in injury or disease. Ongoing studies are evaluating these relationships in hard (i.e., bone) and soft (i.e., tendon, cartilage, intervertebral disc) tissues.